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Kato, M., Nishikawa, S., Ikehata, A., Dochi, K., Tani, T., Takahashi, T., & Tsuda, T

Aim for a urine output of about 2.5 liters a day (pale-straw urine)
Patients with pre-existing GERD often need to adjust these items downward more aggressively than patients without baseline reflux

The full staggered schedule is in the dosing section

This mechanism is designed to help reduce calorie intake and support sustainable portion management when combined with a reduced-calorie diet and increased physical activity