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Search items included medication-related itemsGLP-1 receptor agonist, GLP-1RA, dual-agonist, and glucagon-like peptide-1 along with cardiovascular outcome-related items major adverse cardiovascular event, myocardial infarction, coronary artery disease, peripheral arterial disease, heart failure, hypertension, and atrial fibrillation. Studies were meticulously screened and included if they reported cardiovascular outcomes related to MACE, myocardial infarction (MI), CAD, PAD, HF, hypertension (HTN), or AF
doi: 10.1007/s00125-022-05715-4 131 Snchez-GarridoMABrandtSJClemmensenCMllerTDDiMarchiRDTschpMHet al

The mechanism of prediabetes treatment by natural compounds might be related to decreased IR, reduced lipogenesis, oxidative stress, and inflammation, and improved function of -cells function

A 2023 observational analysis published in the Annals of the Rheumatic Diseases found that patients with inflammatory arthritis who used GLP-1 receptor agonists had lower rates of cardiovascular events, which is notable because cardiovascular disease is a leading cause of death in RA patients
