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Nat Rev Endocrinol 21 , 6566 (2025)

These hormonal shifts can create a state called GLP-1 resistance, where the drugs effect is partially overridden by an unbalanced hormonal environment easily

8 Therefore, given the increasing burden of lean MASLD in some populations and the benefits of GLP-1RA in weight management, more clinical attention is warranted

Both of these medications have demonstrated effectiveness for short and long-term weight loss plans

Both Wegovy forms are made with semaglutide
