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Patients frequently experience improved insulin sensitivity, better glucose regulation, and decreased insulin resistance

According to the people involved in what we can only assume was a somewhat tense exit interview, this is what was said: August Krogh: What are you going to do? Harald Pedersen: We want to make insulin. August Krogh: Well, you'll never manage that. Harald Pedersen: We will show you! We don't have any more records about what happened following this exchange and whether or not hands were shaken, but the Pedersen brothers were determined to keep their promise

Dose escalation impact The standard UK protocol involves gradually increasing the dose: 2.5mg for 4 weeks 5mg for 4 weeks 7.5mg for 4 weeks 10mg for 4 weeks Potentially up to 15mg as a maintenance dose Each dose increase generally provides more consistent between-dose coverage

In PIONEER 3, mean weight loss was -1.3% with semaglutide 3 mg, -2.2% with semaglutide 7 mg, -3.2% with semaglutide 14 mg and -0.6% with sitagliptin from baseline to week 26