is retatrutide a glp 1 Retatrutide—A Game Changer in Obesity Pharmacotherapy is retatrutide a glp 1

Studies have suggested that, compared to standard treatments, GLP-1 RAs offer significant cost savings, particularly when factoring in the reduction of hospitalizations and long-term care associated with stroke-related disabilities

The Independent Validation That Matters One piece of evidence that doesn't get enough attention: in July 2025, a completely independent research group not affiliated with Fractyl published a peer-reviewed study in Nature's Communications Medicine demonstrating that a single genome-editing intervention targeting liver cells could produce sustained GLP-1 receptor agonist secretion

1), GSK3 was found to be inhibited after GLP-1 receptor activation in neuronal cell cultures and animal models of AD and PD [145,146,147]

GLP-1 receptor agonists are potent insulin sensitizers, explains Sonia Gibson, MD, a board-certified physician in endocrinology, diabetes, and metabolism, and the endocrinology physician lead at Allara Health

CAROLYN BRAMANTE: Yeah, thanks for having me