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Treatment for 24 weeks with semaglutide compared to placebo reduced UACR by 52.1% (95% confidence interval 65.5, 33.4

The reported design also incorporated non-native amino acids at positions vulnerable to enzymatic degradation

Multivariate regression analysis was not performed for SURMOUNT4 because tirzepatide dose could not be assessed with the MTD being 15 mg for 93% of participants at randomization

Thats partly because some animal studies suggest the drugs can harm the development of a fetus, but mainly because scientists havent studied the impact on pregnancy in humans

Tirzepatide is very effective for weight loss