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Adverse reactions related to volume depletion (including reports of dehydration, hypovolemia, orthostatic hypotension, or hypotension) for the 12-trial and 13-trial, short-term, placebocontrolled pools and for the DECLARE trial are shown in Table 4 [see WARNINGS AND PRECAUTIONS ]

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26 The SURPASS trials investigated the effect of tirzepatide in participants with T2D and reported weight reductions of 514%

Marks, M

This is fundamentally different from taking liraglutide and semaglutide together