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47,48 GLP-1 agonists impact the dopamine signaling in the mesolimbic pathway and regulate the reward-motivated behavior in alcohol consumption, thus showing potential as a pharmacotherapeutic intervention

Clinicians should judiciously balance potential benefits against risks when considering the use of these agents in pregnant patients and, where feasible, engage in thorough preconception counseling.225,226 Future research should prioritize the evaluation of long-term safety outcomes during pregnancy and potential fetal effects to inform safer clinical practices

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+ GLP-1 Microdosing involves using lower, targeted doses under medical supervision, with the goal of exploring subtle benefits while minimizing intensity

doi: 10.1358/dot.2013.49.9.2020940