asa guidelines for glp-1 agonists Perioperative management of patients taking glucagon-like peptide-1 receptor agonists: a restrictive fasting regimen is not necessary. Comment on Br J Anaesth 2025; 135: 48–78 Clinical Recommendations to Manage Gastrointestinal

The liver's cytochrome P450 enzyme system, particularly CYP3A4, plays a significant role in breaking down these compounds

Zhao T, Parikh P, Bhashyam S, Bolukoglu H, Poornima I, Shen YT, Shannon RP: Direct effects of glucagon-like peptide-1 on myocardial contractility and glucose uptake in normal and postischemic isolated rat hearts

GLP-1 drugs include: While GLP-1 drugs are primarily prescribed for managing diabetes, they have become increasingly popular for their effectiveness in supporting weight loss

doi: 10.17219/acem/171300

"But whether they can be safely used for all people who simply want to lose an extra 10 to 20 pounds is questionable." How the new drugs work GLP-1 receptor agonists mimic the GLP-1 hormone that is naturally released in the gastrointestinal tract in response to eating