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By including all English-language studies on muscle mass loss during GLP-1RA therapy in T2D and obesity from major scientific databases and clinical trial registries, this narrative review synthesizes the current knowledge on the epidemiology and mechanisms of muscle loss in diabetes and obesity, with a focus on the impact of GLP-1RAs therapy

Obesity is a chronic disease associated with increased risk of obesity-related complications and mortality

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Accessing GLP-1 medications without insurance is achievable through compounded formulations, direct-to-consumer providers, and cost-effective protocols

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