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Cardiovascular-related indicators included the incidence of major adverse cardiovascular events (MACE), cardiac function indicators, and the progression of atherosclerotic lesions

To measure publication bias, we performed a funnel plot and Eggers tests

Implications for weight loss drugmakers: Lilly and Novos battle across injectables and pills will define how the category evolves, and raise the bar for new entrants

Lipodystrophy in insulin-treated subjects and other injection-site skin reactions: Are we sure everything is clear

The 2025 review also reported that in a large retrospective study of 461,328 adults initiating GLP-1 therapy, over 22% developed at least one nutritional deficiency within 12 months, with vitamin D the most common deficiency identified