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Furthermore, despite clinical use for over 60 years as an anti-diabetic drug, the cellular mechanisms by which metformin exerts either its actions remain unclear

2024;doi:10.1093/rheumatology/keae547

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For a compound intended for chronic use, that gap in the data is the most important honest limitation to acknowledge

Impact on Waist Circumference & Fat Distribution Research also shows that GLP-1 medications help reduce: Visceral fat (fat around the organs) Liver fat (in patients with fatty liver, NAFLD) Waist size and abdominal fat mass These improvements support cardiovascular health and metabolic stability, not just weight loss