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Description
The US Food and Drug Administration approved this first-in-class medication for the management of type 2 diabetes (T2D) in 2022 [2], for the reduction of excess weight in adults with obesity or overweight in 2023 [3], and for moderate-to-severe obstructive sleep apnea (OSA) in people with obesity in 2024 [4]

Repurposed pharmaceuticals minimize the time and expense associated with discovering novel therapies, as pharmacokinetic and toxicological data for existing medications are readily accessible

Findings: Fifteen studies were included, covering six clinical investigations and nine fundamental research studies

Given that GIP is thought to be important for lipogenesis, the mechanism for this effect of the dual agonist is unclear

Data represents mean SEM
