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Retatrutides mechanism of action involves simultaneously stimulating GLP-1, GIP, and glucagon receptors , each playing a distinct role in metabolism: GLP-1 receptor agonism : Reduces appetite, delays gastric emptying, and improves insulin secretion
It cites clinical trial data for its molecules (15 to 20% for semaglutide, 20 to 22% for tirzepatide from SURMOUNT-1 and STEP)
