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From Systemic Inflammation to Myocardial Fibrosis: The Heart Failure With Preserved Ejection Fraction Paradigm Revisited

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GLP-1 and GLP-1RAs have also shown to exert anti-depressive effects by reversing many maladaptive brain changes relevant to depression (13)
Katsila T., Spyroulias G

Semaglutide also helps weight loss through other actions that do not depend on making sugar low: It reduces appetite and increases fullness by acting on satiety centres in the brain It slows stomach emptying, so you feel full sooner and longer So, in a non-diabetic person, the body still has normal safety systems, and semaglutide mainly helps by reducing calorie intake, not by forcing sugar down
