metformin and glp-1 together Is It Time to Change the Type 2 Diabetes Treatment Paradigm? Yes! RAs Should Replace in the Type 2 Diabetes Algorithm metformin and glp-1 together Involvement

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Athauda D, Gulyani S, Karnati HK, et al

30,31 In clinical trials, systolic BP reduction ranged from 2.8 to 4.4 mmHg

Whereas the DPP-IV degradation can be avoided by substituting Ala 8 with various amino acids like Gly, Ser, d-Ala, and Aib, 32,37 the degradation by NEP 24.11 is hard to address in a similar manner because of the multiple sites that NEP 24.11 targets (Figure 1)

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