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Novo Nordisk has announced it has filed an NDA to FDA for CagriSema (cagrilintide), a once-weekly GLP-1 injection (to be used with a reduced-calorie diet and increased physical activity) to reduce excess body weight and maintain weight reduction long term in adults with obesity or are overweight in the presence of at least one weight-related comorbid condition

Ongoing research regarding regulating circadian rhythm with melatonin implicates melatonin as a possible way to improve leptin resistance

In addition, the dataset lacked information on several potentially important confounders, such as education level, income, and broader social or behavioral factors, which are not routinely collected in clinical care

About the Author Scott Froum, DDS Editorial Director Scott Froum, DDS, a graduate of the State University of New York, Stony Brook School of Dental Medicine, is a periodontist in private practice at 1110 2nd Avenue, Suite 305, New York City, New York