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Instead, they claim that berberine might support your bodys natural GLP-1 production. Even if berberine could modestly influence GLP-1 levels (which is debatable), this would be entirely different from the direct, powerful effects of prescription GLP-1 medications

Jensterle, M., et al., 2015

For a visual sense of what these results look like in real people, semaglutide before-and-after results provide useful reference points

We therefore conclude that before the place of GLP-1/glucagon co-agonists within the therapeutic armamentarium can be defined, future research efforts need to address the following outstanding questions: What is the optimal balance and receptor potency of GLP-1 and glucagon in a long-acting co-agonist, to minimise adverse effects and to optimise efficacy ( Figure 2 )

A meta-analysis of 25 studies indicated that the use of exenatide (OR: 0.86, 95% CI: 0.29-2.60) and liraglutide (OR: 1.35, 95% CI: 0.70-2.59) did not significantly elevate the risk of pancreatic cancer