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Further experiments showed that both congenital adipocyte-specific heterozygous leptin knockout mice and systemic heterozygous leptin knockout mice exhibited resistance to HFD-induced obesity, with consistent effects observed in both male and female mice (112)

This trial represented a watershed moment in the clinical management of these patients

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Data extraction, risk of bias assessment, and meta-analysis were performed using standardized methods with a random-effects model

Safe, effective treatments are still available
