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This is completely normal and is not a sign that anything is wrong or that the medicine is not working
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40.0% ( p = 0.04)
In addition to the drug or placebo injection, participants received individual counselling sessions every 4 weeks to help them adhere to a reduced-calorie diet (500 calories deficit per day relative to their own starting calorie intake) and increased physical activity (150 minutes a week)
Instead, the weight loss achieved in the clinical trials was the result of months of support from doctors, dietitians, physical activity advisors, nurses etc
