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In the 2022 SURMOUNT-1 study published in NEJM, three doses of tirzepatide were compared with placebo (1:1:1:1) to determine effects on percent weight change over the course of 72 weeks

For patients first prescribed an AOM in June 2025, 46.8% filled a GLP-1 RA within 60 days

[DOI] [PubMed] [Google Scholar] 96.Ahmann AJ, Capehorn M, Charpentier G, et al

Deaths ( n = 60) in total occurred in the study, 25 (3%) in the tirzepatide arms and five (4%) in the insulin glargine arm (HR, 0.70

In an era increasingly defined by complex, multifactorial diseases, such systems may be better suited to therapeutic intervention than narrowly targeted pathways optimized for reductionist endpoints