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Over a period of 4 to 8 weeks, as you move from the initial titration doses to higher therapeutic levels, the decrease in hunger becomes a steady state rather than a fluctuating feeling

The primary goal of treatment should extend beyond weight loss to encompass the preservation of lean mass, improvement in metabolic health, and long-term prevention of obesity-related complications [7]
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Walters JRF, Johnston IM, Nolan JD, et al

Expanded approvals : Trials are ongoing for fatty liver disease, cardiovascular prevention in non-diabetics, and neurodegenerative disorders