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Description
Although GLP-1R expression is relatively low in many peripheral organs, GLP-1 medicines exert distinct antiinflammatory effects through both direct and indirect mechanisms that involve immune, vascular, and neural crosstalk (Figure 4)

Differential hypothalamic neuronal activation following peripheral injection of GLP-1 and oxyntomodulin in mice detected by manganese enhanced magnetic resonance imaging

However, the outcome can vary depending on individual factors such as diet and exercise
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Results Patient population We included 78,781 patients who had both a prescription for a GLP-1 receptor agonist (GLP-1 RA) and a documented reason for discontinuing the medication between June 2021 and December 2024 (Table 1)

They need exogenous insulin to survive