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In the phase 2 trial, 41% to 63% of participants receiving cagrilintide (0.3 to 4.5 mg) experienced gastrointestinal adverse events, compared to 32% with placebo

This strategy can lead to additivity in weight loss and metabolic improvements, which more closely mirror the effects of metabolic procedures

maintaining the same weights week over week is not enough to signal preservation

These results prompted the hypothesis on a direct role of GLP-1 in controlling pubertal development through the hypothalamic GnRH secretion, although this mechanism still remains to be unraveled

Bendotti G, Montefusco L, Pastore I, et al
