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These effects were dose-dependent and particularly pronounced at higher doses

Both pathways protect retinal cells (including RGCs) from damage induced by high glucose or ischemic conditions

However, if this severe elevation is accompanied by symptoms such as chest pain, severe headache, shortness of breath, neurological symptoms, or confusion, patients should call 911 immediately as this represents a hypertensive emergency requiring urgent treatment

However, an unphysiologically large postprandial release of GLP1, for example, after gastric bypass surgery (Korner et al., 2007), might reach the circumventricular organs, and DPP4resistant GLP1 receptor agonists clearly have central actions, though whether this includes action on GLP1 receptors inside the BBB or is limited to direct activation of GLP1 receptors in the circumventricular organs outside the BBB, is less clear (Adams et al., 2018

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