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It makes sense that thats where the mechanism of action is. The brain was always involved, he says, but these new drugs are helping researchers zero in on the brain as a center for regulating energy in and energy out. Appetitethe drive to eatis biologically motivated by three core sensations: hunger, fullness and reward
Its receptor GLP-1R is mainly expressed in islet cells in the pancreas, and is also widely expressed in tissues such as stomach, small intestine, heart, kidney, lung and brain
