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While some patients report feeling more optimistic and energized, there have been reports of depression and suicidal thoughts, particularly with semaglutide

Because these drugs affect how the brain processes reward, there may be a possibility that it also can dull pleasurable experiences

Moreover, 1 recent study assessed the presence of peripherally injected semaglutide in the NAc of male and female rats and found the GLP-1 analog in the NAc of both males and females (141)

Taking GLP-1s has been shown to reduce markers of inflammation

In the past 5 years, she has been euthymic on venlafaxine 225 mg/day and trazodone 12.5 mg/night