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They wrote in the journal Regional Anesthesia and Pain Medicine: "These findings suggest that GLP- 1 RAs, particularly newer agents used over sustained durations, may represent a meaningful complementary strategy within non- surgical knee OA management for eligible patients with concurrent obesity or metabolic disease." They added: "In this large, multicentre, real-world cohort study, GLP- 1 RA use was associated with a significantly reduced long term risk of TKA (total knee arthroplasty) in patients with knee OA, with effects that were greater with longer treatment duration and newer generation agents

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