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The MIR21 gene, located in TMEM49 gene on chromosome 17q23.2 [48], has been well characterized in many complications diabetes-related, such as diabetic retinopathy [49], kidney fibrosis [50], diabetic nephropathy [19], and insulin resistance (IR) [19]

The standard dosing schedule is: Month 1: 0.25 mg once a week Month 2: 0.5 mg once a week Month 3: 1 mg once a week Month 4: 1.7 mg once a week Month 5 and beyond: 2.4 mg once a week After you increase to 2.4 mg, you have completed the escalation process and will continue to use the 2.4 mg semaglutide for as long as you take the drug

If constipation persists despite these measures, healthcare providers may consider temporarily delaying dose increases or reducing the tirzepatide dose

The skills you build during treatment like portion awareness, regular meal timing, and consistent exercise are what enable weight maintenance in the long term

According to medical literature, discontinuation of treatment typically leads to regaining weight, suggesting that the injection might need to be taken for life