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However, the ominous octet as described by DeFronzo, suggests that multiple drugs targeting different metabolic abnormalities in type 2 diabetes are required to reduce subsequent morbidity and mortality [7]

The first studies evaluating the effects of GLP-1 and exendin-4 in neuronal cells demonstrated their ability to promote neurite outgrowth (a similar effect to that observed with the neurotrophic nerve growth factor) and to protect cultured neurons against glutamate-induced apoptosis [33]

These drugs are prescribed not only for type 2 diabetes but increasingly for chronic weight management, particularly in adults with a body mass index indicating obesity or overweight status with related health risks

Furthermore, accumulating evidence has indicated that gut serotonin communicates with the serotonergic signaling in the brain via the gutbrain axis, and vice versa [17]

Cinnamon is high in fiber