glp-1 produced by GLP-1: Actions on Beta-cell Mass and Function Unlocking the multifaceted roles of

Lancet 403 , 10271050 (2024)

[DOI] [PMC free article] [PubMed] [Google Scholar] 159.Thyssen S., Arany E., Hill D.J

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As a synthetic analog of its endogenous exendin-4, compared with exendin-4, LIXI deleted one proline and added six lysine residues, which increased its binding affinity with the GLP-1R by four times and increased its circulating half-life ( A prospective clinical study from Spain found that besides controlling blood glucose (fasting blood glucose and glycosylated hemoglobin), LIXI can also improve blood lipids, especially total cholesterol and triglyceride ( In clinical studies, LIXI has shown the benefits of weight loss, which is well tolerated by patients and can meet the needs of overweight patients for weight control

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