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These additions are generally well-tolerated, but in some individuals, they can slightly alter digestive response

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c Duration presented as median follow-up length in years

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These findings, revealed more than a decade after the first approval of twice-daily exenatide in 2005, have rekindled enthusiasm for the use of GLP-1R agonists, alone or in combination, in the treatment of T2D and obesity, most compellingly in subjects at high risk for cardiovascular disease