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LAMP3 inhibits autophagy and contributes to cell death by lysosomal membrane permeabilization

doi: 10.3390/ijms26010364

Alkhouri N, Herring R, Kabler H, Kayali Z, Hassanein T, Kohli A, et al

Mice treated with GLP-1MK-801 for 14 days exhibited lower plasma insulin levels compared with both vehicle-treated mice and those treated with MK-801 alone (Fig

Although DSM-5 diagnosis is defined through multiple behavioral criteria encompassing impaired control, social dysfunction, continued use despite harm, and tolerance or withdrawal, converging clinical and preclinical evidence indicates that the core pathological feature of SUDs is the progressive loss of control over intake (O'Brien, 2005)