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Some studies suggest that a notable portion of people taking GLP-1 medications develop at least one nutritional deficiency within the first year

While a single study cannot be considered definitive, a 65% risk reduction across nearly 300,000 matched pairs is difficult to dismiss
doi: 10.1053/j.gastro.2004.04.063 27 SmitsMMTonneijckLMuskietMHAKramerMHHCahenDLvan RaalteDH

An important exception includes individuals with a personal or family history of medullary thyroid carcinoma (MTC), where GLP-1 RAs are contraindicated
Glucagon, the ligand of GCGR, increases insulin secretion via GCGR and GLP-1R in pancreatic cells, although GLP-1R is the main insulin-promoting receptor
