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These findings suggest that a decrease in NAD + levels is involved in the pathogenesis of age- and obesity-related diseases in humans and rodents

The life expectancy of people with T2D is reduced due to increased mortality from cardiovascular disease (CVD)

Nadler says
So when you eat something, it gives you the signal: eat this again

That may sound like a dramatic prediction, but it is the conclusion I reached after reviewing a document we recently uncovered (January 12th, 2026) regulatory filing submitted by Novo Nordisk to the U.S
