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The recommended starting doses are as follows: For patients nave to basal insulin or to a GLP-1 RA, currently on less than 30 units of basal insulin, or on a GLP-1 RA: Start at 15 units subcutaneously once daily within 60 minutes of the first meal of the day

The pathways include inflammation, vascular damage, mitochondrial dysfunction, the effects of insulin resistance (IR) on metabolism in the brain, the formation of advanced glycation end products (AGEs), and the aggregation of pathological proteins such as A and -synuclein [12]

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T.LinS.et al (2020)

Long-term success for patients taking GLP-1s likely looks like patient-centered care programs where individuals arent just receiving the drug but are also placed within a supportive framework that can monitor their health and adjust treatments or approaches as needed