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Surgical treatment of lymphedema: A systematic review and meta-analysis of controlled trials
Although proper UPR acts as protective against misfolding, enhancing the ER folding capacity and misfolded proteins degradation, excessive or persistent UPR can trigger cellular damage, which leads to apoptosis [135]
Leptin mediates the increase in blood pressure associated with obesity
Additionally, SGLT2is have demonstrated beneficial effects on MASLD, showing histologically proven improvements in hepatic steatosis, inflammation, and fibrosis 6,7,8
