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NEJM 2011;365:15971604: 10.1056/NEJMoa1105816

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Back Jin, T (May 2023) 'Tirzepatide, a new class of incretin-based drug for diabetes' , Obesity Medicine , 39, 1000483

Results In HAP, cumulatively applied retatrutide alone (in the absence of a PDE inhibitor) elevated FOC within 10 min of incubation starting at 10 nM and reaching plateau at 100 nM retatrutide

For insulin-resistant patients, this dual actionappetite reduction plus metabolic improvementaddresses the root problem rather than forcing the body to fight against its own hormonal imbalance