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According to Cleveland Clinic research, nearly half of patients stop taking GLP-1 drugs because of cost
This can be linked to a significant reduction of serine palmitoyl transferase (SPT) protein levels and the downregulation of the ceramide-synthesis enzymes ceramide synthase 5 ( CERS5 ) and delta(4)-desaturase as well as sphingolipid 1 ( DEGS1 ) expression at both messenger-RNA and protein levels
In addition, several RCTs have shown that the DPP4i are also associated with lower insulin dose requirements [17,18,19]
Ann Intern Med 2023;176(4):582583
