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People can and do change their minds, of course, and there are certainly many people who may come around to the idea of utilizing GLP-1 as the user base grows and the effectiveness of the drugs becomes more apparent

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doi: 10.1152/ajpendo.00429.2014

In the biggest phase 3 study that looked at orforglipron stacked up against a placebo in patients with diabetes , weight reduction on the largest dose (36mg) was 7.9% over 40 weeks

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