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Protein and exercise recommendations in this article are general and may not be appropriate for individuals with specific health conditions including kidney disease, cardiovascular disease, or orthopedic limitations

This information assists your physician in determining whether fatigue relates to the medication, requires dose adjustment, or necessitates further diagnostic evaluation
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A 2021 clinical trial published in The New England Journal of Medicine the STEP 1 trial showed that participants on semaglutide lost an average of 14.9% of body weight, but research on the body composition breakdown of that loss suggests a meaningful proportion can come from lean mass rather than fat, particularly when protein intake is inadequate