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The most frequent adverse events in the semaglutide treatment arms were gastrointestinal, although these were mostly transient and mild to moderate in severity

In fact, for a lot of patients, we start their weight loss journey with bio-identical hormone replacement therapy (BHRT) before medications like GLP-1 in Kansas City

NICE recommends GLP-1 therapy for type 2 diabetes (NG28) when: HbA1c remains elevated despite dual therapy with metformin and another oral agent The patient has a BMI of 35 kg/m or higher (or lower thresholds for certain ethnic groups) Significant weight loss would benefit other obesity-related comorbidities Insulin therapy poses specific risks or is declined by the patient For weight management, NICE has approved specific GLP-1 receptor agonists through Technology Appraisals

2020The dual glucose-dependent insulinotropic peptide and glucagon-like peptide-1 receptor agonist, tirzepatide, improves lipoprotein biomarkers associated with insulin resistance and cardiovascular risk in patients with type 2 diabetes