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Despite this, the FDA (Food and Drug Administration) expressed support for further testing in phase III trials, suggesting that tesofensine could be a safe and effective long-term treatment for obesity, with minimal effects on the cardiovascular system

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For example, there are some people who are advised not to take the medication, including those who have a personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN 2)

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Clinical studies and meta-analyses have identified an increased risk of gallbladder disease with GLP-1 receptor agonist use, particularly with weight loss medications