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The inhibitor action of GLP-1 on glucagon levels is often over-looked in favor of its role as an insulin secretagogue, but it is clear that pharmacologically this is one mechanism by which GLP-1r agonists improve glycemia in T2DM patients (86)

Almost three decades ago, the discovery of leptin triggered a new era of molecular obesity research

Additional studies are needed to determine whether SGLT2 inhibitors can meaningfully delay kidney disease progression in people with non-albuminuric or non-proteinuric DKD

Moreover, the GLP-1R knockout mice self-administered more nicotine than their wildtype counterparts (Tuesta et al., 2012)

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