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JACC Heart Fail 6:10081010

Because you're not eating as much, you may not be getting the fiber you need to bulk up stool and keep things moving smoothly, which can also lead to constipation (especially if you're also not drinking enough fluids), says Hamilton

The key words used were combinations of the following: GLP-1 agonists, pathophysiology, stroke, stroke prevention, outcomes, complications and therapy

A major contributor was prescription drug spending, which rose 9.4% in 2025, driven in part by growing use of GLP-1 medications, some of which have list prices exceeding $1,000 per month, according to various estimates

Retatrutide benefits from targeting three receptors, which may explain the impressive early research results