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In a later interview with People , published in December 2025, Winfrey revealed that just six months after starting GLP-1s, shed decided to see if she could beat the medication by stopping taking them

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The investigational drug, a once-weekly injectable targeting GLP1, GIP, and glucagon receptors, is designed to regulate appetite and metabolism through multiple hormone pathways

If you suspect an adverse reaction to a GLP-1 medication, report it to the MHRA Yellow Card scheme (yellowcard.mhra.gov.uk)

This is one reason many endocrinologists prefer injectable GLP-1 medications for patients on thyroid hormone replacement