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BMI reduced by a mean of 2.7 (3) kg/m 2

After 12 months of treatment: Combination group (HRT plus semaglutide): approximately 16% total body weight loss average Monotherapy group (semaglutide alone): approximately 12% total body weight loss average Nearly 50% of combination therapy patients achieved 20% total body weight reduction Only 18% of monotherapy patients achieved 20% total body weight reduction Researchers proposed potential mechanisms for enhanced efficacy including: improved sleep quality from HRT reducing night sweats supporting exercise adherence and recovery, mood stabilization potentially improving motivation and treatment compliance, reduced systemic inflammation supporting metabolic health, and enhanced energy levels facilitating increased physical activity

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Treatment intensification with stepwise addition of prandial insulin aspart boluses compared with full basal-bolus therapy (FullSTEP Study): a randomised, treat-to-target clinical trial