first generic glp 1 of Once-Daily GLP-1 Injection Approved for Diabetes The Rise of GLP-1 Medications

Safety concerns were also raised in a phase 1 trial investigating the GLP-1R/GCGR agonist NNC9204-117, where a dose-dependent increase in heart rate was observed, in addition to increased markers of inflammation, hepatic disturbances, impaired glucose tolerance, and reduced blood levels of some amino acids despite clinically relevant weight loss (Friedrichsen et al

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National Institute for Health and Care Excellence: Type 2 diabetes in adults: management

Rare but serious risks include: Pancreatitis : Severe abdominal pain should prompt immediate medical attention Gallbladder problems : Rapid weight loss can increase gallstone risk Diabetic retinopathy complications : In people with existing eye disease, rapid glucose improvement may temporarily worsen retinopathy, particularly with semaglutide [14] [15] Hypoglycaemia : Low blood sugar is uncommon with GLP-1 agonists alone but can occur if combined with insulin or sulphonylureas [17] [18] GLP-1 agonists are not recognised to directly cause dangerous blood pressure drops (hypotension) in most patients

NY Acad