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Evidence has recently revealed that GLP-1RAs inhibit cardiac hypertrophy by upregulating GLP-1R expression and activating the AMPK/mechanistic target of the rapamycin (mTOR) signaling pathway [78]

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Angerbauer argues that preventive treatments for healthy adults should be held to a higher standard because healthy people have less to gain and more to lose from potential side effects, making it essential to demonstrate a clear and substantial net benefit

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Tirzepatide added GIP receptor activation to GLP-1, demonstrating that multi-receptor approaches could enhance weight loss without proportionally increasing side effects