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more data are needed on the implications of GLP-1 RA discontinuation-associated gestational weight gain for long-term weight retention in mothers and programming effects in offspring that may be independent of birth weight, the authors wrote

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doi: 10.18502/ijph.v50i12.7926

In contrast, insulin primarily affects fasting glucose levels with minimal influence on post meal glucose levels and no relation to gastric emptying ( The improved regulation of glycemia by GLP-1RA, along with their ability to reduce lipid synthesis, enhanced beta oxidation of free fatty acids and autophagy of fat cells contributes to their lipid modulation properties ( Oral semaglutide has been found to improve fasting blood glucose levels in a trial conducted over a 12 week period with improved levels of triglycerides, very low-density lipoprotein (VLDL), low- density lipoprotein (LDL) and apolipoprotein B48 (ApoB48) and no change in high density lipoprotein (HDL) ( 4.5 Musculoskeletal effects T2DM raises the risk of fractures, poor bone repair, and other factors that lead to brittle bones ( A study that investigated the effects of insulin and GLP-1RAs (exenatide and dulaglutide) on BMD over a 52-week duration gathered 70 individuals with type 2 diabetes